Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis

Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we used precision-cut kidney slices (PCKS) as a model o...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Bigaeva, Emilia, Puerta Cavanzo, Nataly, Stribos, Elisabeth G. D., de Jong, Amos J., Biel, Carin, Mutsaers, Henricus A. M., Jensen, Michael S., Nørregaard, Rikke, Leliveld, Anna M., de Jong, Igle J., Hillebrands, Jan-Luuk, van Goor, Harry, Boersema, Miriam, Bank, Ruud A., Olinga, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285118/
https://ncbi.nlm.nih.gov/pubmed/32443499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12050459
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