Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis

Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we used precision-cut kidney slices (PCKS) as a model o...

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Bibliografiska uppgifter
I publikationen:Pharmaceutics
Huvudupphovsmän: Bigaeva, Emilia, Puerta Cavanzo, Nataly, Stribos, Elisabeth G. D., de Jong, Amos J., Biel, Carin, Mutsaers, Henricus A. M., Jensen, Michael S., Nørregaard, Rikke, Leliveld, Anna M., de Jong, Igle J., Hillebrands, Jan-Luuk, van Goor, Harry, Boersema, Miriam, Bank, Ruud A., Olinga, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285118/
https://ncbi.nlm.nih.gov/pubmed/32443499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12050459
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