The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box–Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...

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Bibliografiska uppgifter
I publikationen:Pharmaceutics
Huvudupphovsmän: Szymańska, Emilia, Woś-Latosi, Katarzyna, Jacyna, Julia, Dąbrowska, Magdalena, Potaś, Joanna, Markuszewski, Michał Jan, Winnicka, Katarzyna
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284795/
https://ncbi.nlm.nih.gov/pubmed/32429349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12050455
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