The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box–Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...

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Dettagli Bibliografici
Pubblicato in:Pharmaceutics
Autori principali: Szymańska, Emilia, Woś-Latosi, Katarzyna, Jacyna, Julia, Dąbrowska, Magdalena, Potaś, Joanna, Markuszewski, Michał Jan, Winnicka, Katarzyna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284795/
https://ncbi.nlm.nih.gov/pubmed/32429349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12050455
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