Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E

Increasing resistance of bacteria to antibiotics is a serious global challenge and there is a need to unlock the potential of novel antibacterial targets. One such target is the essential prokaryotic endoribonuclease RNase E. Using a combination of in silico high-throughput screening and in vitro va...

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Publicado no:Biochem Biophys Rep
Main Authors: Mardle, Charlotte E., Goddard, Layla R., Spelman, Bailei C., Atkins, Helen S., Butt, Louise E., Cox, Paul A., Gowers, Darren M., Vincent, Helen A., Callaghan, Anastasia J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284133/
https://ncbi.nlm.nih.gov/pubmed/32548313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100773
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