Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

Pharmacological inhibitors of Bruton tyrosine kinase (BTK) have revolutionized treatment of B-lymphocyte malignancies and show great promise for dampening autoimmunity. The predominant BTK inhibitors tether irreversibly by covalently binding to cysteine 481 in the BTK catalytic domain. Substitution...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood Adv
Principais autores: Estupiñán, H. Yesid, Bouderlique, Thibault, He, Chenfei, Berglöf, Anna, Gupta, Dhanu, Saher, Osama, Daza Cruz, Miguel Ángel, Peña-Perez, Lucia, Yu, Liang, Zain, Rula, Karlsson, Mikael C. I., Månsson, Robert, Smith, C. I. Edvard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284087/
https://ncbi.nlm.nih.gov/pubmed/32492159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001319
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados