Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

Pharmacological inhibitors of Bruton tyrosine kinase (BTK) have revolutionized treatment of B-lymphocyte malignancies and show great promise for dampening autoimmunity. The predominant BTK inhibitors tether irreversibly by covalently binding to cysteine 481 in the BTK catalytic domain. Substitution...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Estupiñán, H. Yesid, Bouderlique, Thibault, He, Chenfei, Berglöf, Anna, Gupta, Dhanu, Saher, Osama, Daza Cruz, Miguel Ángel, Peña-Perez, Lucia, Yu, Liang, Zain, Rula, Karlsson, Mikael C. I., Månsson, Robert, Smith, C. I. Edvard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284087/
https://ncbi.nlm.nih.gov/pubmed/32492159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001319
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