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Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors

Low-molecular weight chemical compounds have a longstanding history as drugs. Target specificity and binding efficiency represent major obstacles for small molecules to become clinically relevant. Protein kinases are attractive cellular targets; however, they are challenging because they present one...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zain, Rula, Vihinen, Mauno
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328433/
https://ncbi.nlm.nih.gov/pubmed/34349760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.694853
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