The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

Insulin resistance and hepatic lipid accumulation constitute the metabolic underpinning of nonalcoholic steatohepatitis (NASH). We tested the hypothesis that saroglitazar, a PPAR α/γ agonist would improve NASH in the diet-induced animal model of NAFLD. Mice received chow diet and normal water (CDNW)...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kumar, Divya P., Caffrey, Rebecca, Marioneaux, Jonathon, Santhekadur, Prasanna K., Bhat, Madhavi, Alonso, Cristina, Koduru, Srinivas V., Philip, Binu, Jain, Mukul R., Giri, Suresh R., Bedossa, Pierre, Sanyal, Arun J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283326/
https://ncbi.nlm.nih.gov/pubmed/32518275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66458-z
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