The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription

Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C), two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. Thus, it is essential to understand the regulatory network modulating the CDK8-CycC complex i...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Li, Xiao, Liu, Mengmeng, Ren, Xingjie, Loncle, Nicolas, Wang, Qun, Hemba-Waduge, Rajitha-Udakara-Sampath, Yu, Stephen H., Boube, Muriel, Bourbon, Henri-Marc G., Ni, Jian-Quan, Ji, Jun-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282676/
https://ncbi.nlm.nih.gov/pubmed/32463833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008832
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