R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

BACKGROUND: Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region, connecting the ligand binding and DNA domains. rs142712646 is a rare SNP...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Boldes, Tomer, Merenbakh-Lamin, Keren, Journo, Shani, Shachar, Eliya, Lipson, Doron, Yeheskel, Adva, Pasmanik-Chor, Metsada, Rubinek, Tami, Wolf, Ido
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282172/
https://ncbi.nlm.nih.gov/pubmed/32513126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07005-x
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