A Novel Role for NUAK1 in Promoting Ovarian Cancer Metastasis through Regulation of Fibronectin Production in Spheroids

Epithelial ovarian cancer (EOC) has a unique mode of metastasis, where cells shed from the primary tumour, form aggregates called spheroids to evade anoikis, spread through the peritoneal cavity, and adhere to secondary sites. We previously showed that the master kinase Liver kinase B1 (LKB1) is req...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Fritz, Jamie Lee, Collins, Olga, Saxena, Parima, Buensuceso, Adrian, Ramos Valdes, Yudith, Francis, Kyle E., Brown, Kevin R., Larsen, Brett, Colwill, Karen, Gingras, Anne-Claude, Rottapel, Robert, Shepherd, Trevor G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280971/
https://ncbi.nlm.nih.gov/pubmed/32429240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12051250
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