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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression of many types of tumors and thus β-catenin represents one attractive intracellular target for cancer therapy. Based on the Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 and x...
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| Publicado no: | Cell Discov |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Singapore
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7280531/ https://ncbi.nlm.nih.gov/pubmed/32550000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0171-1 |
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