Iron overload alters the energy metabolism in patients with myelodysplastic syndromes: results from the multicenter FISM BIOFER study

Myelodysplastic syndromes (MDS) are hematological malignancies characterized by ineffective hematopoiesis and increased apoptosis in the bone marrow, which cause peripheral cytopenia. Mitochondria are key regulators of apoptosis and a site of iron accumulation that favors reactive oxygen species (RO...

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Publicado no:Sci Rep
Main Authors: Cilloni, Daniela, Ravera, Silvia, Calabrese, Chiara, Gaidano, Valentina, Niscola, Pasquale, Balleari, Enrico, Gallo, Daniela, Petiti, Jessica, Signorino, Elisabetta, Rosso, Valentina, Panuzzo, Cristina, Sabatini, Federica, Andreani, Giacomo, Dragani, Matteo, Finelli, Carlo, Poloni, Antonella, Crugnola, Monica, Voso, Maria Teresa, Fenu, Susanna, Pelizzari, Annamaria, Santini, Valeria, Saglio, Giuseppe, Podestà, Marina, Frassoni, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280296/
https://ncbi.nlm.nih.gov/pubmed/32514107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66162-y
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