Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization

Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, e.g. liquid-formulated vaccines w...

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Pubblicato in:Sci Rep
Autori principali: Doekhie, A., Dattani, R., Chen, Y-C., Yang, Y., Smith, A., Silve, A. P., Koumanov, F., Wells, S. A., Edler, K. J., Marchbank, K. J., Elsen, J. M. H. van den, Sartbaeva, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280242/
https://ncbi.nlm.nih.gov/pubmed/32513957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65876-3
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