Plasmin improves blood–gas barrier function in oedematous lungs by cleaving epithelial sodium channels

BACKGROUND AND PURPOSE: Lung oedema in association with suppressed fibrinolysis is a hallmark of lung injury. Here, we have tested whether plasmin cleaves epithelial sodium channels (ENaC) to resolve lung oedema fluid. EXPERIMENTAL APPROACH: Human lungs and airway acid‐instilled mice were used for a...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Zhao, Runzhen, Ali, Gibran, Nie, Hong‐Guang, Chang, Yongchang, Bhattarai, Deepa, Su, Xuefeng, Zhao, Xiaoli, Matthay, Michael A., Ji, Hong‐Long
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280014/
https://ncbi.nlm.nih.gov/pubmed/32133621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15038
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