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Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling
BACKGROUND AND PURPOSE: GPCRs can signal through both G proteins and β‐arrestin2. For the μ‐opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β‐arrestin2 signalling mediates respiratory depression and constipation. Conseq...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7280004/ https://ncbi.nlm.nih.gov/pubmed/32052419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15004 |
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