Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

BACKGROUND AND PURPOSE: GPCRs can signal through both G proteins and β‐arrestin2. For the μ‐opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β‐arrestin2 signalling mediates respiratory depression and constipation. Conseq...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Kliewer, Andrea, Gillis, Alexander, Hill, Rob, Schmiedel, Frank, Bailey, Chris, Kelly, Eamonn, Henderson, Graeme, Christie, Macdonald J., Schulz, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280004/
https://ncbi.nlm.nih.gov/pubmed/32052419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15004
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