COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

INTRODUCTION: COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial c...

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Bibliografiske detaljer
Udgivet i:Int J Chron Obstruct Pulmon Dis
Main Authors: Poh, Wee-Peng, Kicic, Anthony, Lester, Susan E, Nguyen, Phan T, Bakaletz, Lauren O, Reynolds, Paul N, Hodge, Sandra, Roscioli, Eugene
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279738/
https://ncbi.nlm.nih.gov/pubmed/32581530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S245819
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