COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

INTRODUCTION: COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial c...

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Detalhes bibliográficos
Publicado no:Int J Chron Obstruct Pulmon Dis
Main Authors: Poh, Wee-Peng, Kicic, Anthony, Lester, Susan E, Nguyen, Phan T, Bakaletz, Lauren O, Reynolds, Paul N, Hodge, Sandra, Roscioli, Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279738/
https://ncbi.nlm.nih.gov/pubmed/32581530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S245819
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