APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF

Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. However, the molecular mechanism of APE1 biological role...

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Udgivet i:Int J Mol Sci
Main Authors: Choi, Yoo-Duk, Jung, Ji-Yeon, Baek, Minwoo, Khan, Sheema, Song, Peter I., Ryu, Sunhyo, Koo, Joo-Yeon, Chauhan, Subhash C., Tsin, Andrew, Choi, Chan, Kim, Won Jae, Kim, Mihwa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279477/
https://ncbi.nlm.nih.gov/pubmed/32438692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103586
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