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Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling
T cell activation is initiated when ligand binding to the T cell receptor (TCR) triggers intracellular phosphorylation of the TCR-CD3 complex. However, it remains unknown how biophysical properties of TCR engagement result in biochemical phosphorylation events. Here, we constructed an optogenetic to...
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| Udgivet i: | Int J Mol Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7279048/ https://ncbi.nlm.nih.gov/pubmed/32429097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103498 |
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