Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state

Deletion of murine Thm1, an intraflagellar transport A (IFT-A) component that mediates ciliary protein trafficking, causes hyperphagia, obesity and metabolic syndrome. The role of Thm1 or IFT-A in adipogenesis and insulin sensitivity is unknown. Here we report that Thm1 knock-down in 3T3–L1 pre-adip...

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Udgivet i:FASEB J
Main Authors: Jacobs, Damon T, Allard, Bailey A, Pottorf, Tana S, Silva, Luciane M, Wang, Wei, Al-Naamani, Aisha, Agborbesong, Ewud, Wang, Tao, Carr, Dajanae A, Tran, Pamela V
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278885/
https://ncbi.nlm.nih.gov/pubmed/31914634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900751R
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