Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease and obesity. THM1 (also termed TTC21B or IFT139) enc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Jacobs, Damon T., Silva, Luciane M., Allard, Bailey A., Schonfeld, Michael P., Chatterjee, Anindita, Talbott, George C., Beier, David R., Tran, Pamela V.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958314/
https://ncbi.nlm.nih.gov/pubmed/27482817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.025791
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