Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC

The plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates the activity of diverse ion channels to include the epithelial Na(+) channel ENaC. Whether PIP(2) regulation of ENaC is due to a direct phospholipid-protein interaction, remains obscure. To date, possible inter...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Archer, Crystal R., Enslow, Benjamin T., Carver, Chase M., Stockand, James D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278353/
https://ncbi.nlm.nih.gov/pubmed/32341072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012606
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