Genetic Variants in the 3’UTR of BRCA1 and BRCA2 Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer (HBOC) syndrome is mainly caused by mutations in the BRCA1 and BRCA2 genes. The 3’UTR region allows for the binding of microRNAs, which are involved in genetic tune regulation. We aimed to identify allelic variants on 3’UTR miRNA-binding sites in the BRCA1 and BR...

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Detaylı Bibliyografya
Yayımlandı:Diagnostics (Basel)
Asıl Yazarlar: Sánchez-Chaparro, María Marisela, Garza-Veloz, Idalia, Zayas-Villanueva, Omar Alejandro, Martinez-Fierro, Margarita L., Delgado-Enciso, Iván, Gomez-Govea, Mayra Alejandra, Martínez-de-Villarreal, Laura Elia, Reséndez-Pérez, Diana, Rodríguez-Sánchez, Iram Pablo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277914/
https://ncbi.nlm.nih.gov/pubmed/32414209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/diagnostics10050298
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