Genetic Variants in the 3’UTR of BRCA1 and BRCA2 Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer (HBOC) syndrome is mainly caused by mutations in the BRCA1 and BRCA2 genes. The 3’UTR region allows for the binding of microRNAs, which are involved in genetic tune regulation. We aimed to identify allelic variants on 3’UTR miRNA-binding sites in the BRCA1 and BR...

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Publicado no:Diagnostics (Basel)
Main Authors: Sánchez-Chaparro, María Marisela, Garza-Veloz, Idalia, Zayas-Villanueva, Omar Alejandro, Martinez-Fierro, Margarita L., Delgado-Enciso, Iván, Gomez-Govea, Mayra Alejandra, Martínez-de-Villarreal, Laura Elia, Reséndez-Pérez, Diana, Rodríguez-Sánchez, Iram Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277914/
https://ncbi.nlm.nih.gov/pubmed/32414209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/diagnostics10050298
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