How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models

Currently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered orally has several barriers to overcome as it is degraded by the stomach’s low pH, enzymatic content, and...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Amaral, Mariana, Martins, Ana Sofia, Catarino, José, Faísca, Pedro, Kumar, Pradeep, Pinto, João F., Pinto, Rui, Correia, Isabel, Ascensão, Lia, Afonso, Ricardo A., Gaspar, M. Manuela, Charmier, Adília J., Figueiredo, Isabel Vitória, Reis, Catarina Pinto
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277740/
https://ncbi.nlm.nih.gov/pubmed/32349416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10050675
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