Machine learning-based genome-wide interrogation of somatic copy number aberrations in circulating tumor DNA for early detection of hepatocellular carcinoma

BACKGROUND: DNAs released from tumor cells into blood (circulating tumor DNAs, ctDNAs) carry tumor-specific genomic aberrations, providing a non-invasive means for cancer detection. In this study, we aimed to leverage somatic copy number aberration (SCNA) in ctDNA to develop assays to detect early-s...

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Gepubliceerd in:EBioMedicine
Hoofdauteurs: Tao, Kaishan, Bian, Zhenyuan, Zhang, Qiong, Guo, Xu, Yin, Chun, Wang, Yang, Zhou, Kaixiang, Wan, Shaogui, Shi, Meifang, Bao, Dengke, Yang, Chuhu, Xing, Jinliang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276513/
https://ncbi.nlm.nih.gov/pubmed/32512514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102811
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