4-Hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone induces apoptosis in retinal pigment epithelial cells

Retinal pigment epithelial (RPE) cell dysfunction and death play vital roles in age-related macular degeneration (AMD) pathogenesis. Previously we showed that oxidative cleavage of docosahexenoate (DHA) phospholipids generates an α, β-unsaturated aldehyde, 4-hydroxy-7-oxohept-4-enoic acid (HOHA) lac...

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Pubblicato in:Free Radic Biol Med
Autori principali: Linetsky, Mikhail, Guo, Junhong, Udeigwe, Emeka, Ma, Duoming, Chamberlain, Amanda S., Yu, Annabelle O., Solovyova, Kseniya, Edgar, Elise, Salomon, Robert G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276294/
https://ncbi.nlm.nih.gov/pubmed/32222470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.03.017
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