Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

BACKGROUND: MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome sequencing studies have directly implicated MBD5 in the etiology of autism spec...

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Bibliografiske detaljer
Udgivet i:Mol Autism
Main Authors: Seabra, Catarina M., Aneichyk, Tatsiana, Erdin, Serkan, Tai, Derek J. C., De Esch, Celine E. F., Razaz, Parisa, An, Yu, Manavalan, Poornima, Ragavendran, Ashok, Stortchevoi, Alexei, Abad, Clemer, Young, Juan I., Maciel, Patricia, Talkowski, Michael E., Gusella, James F.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275313/
https://ncbi.nlm.nih.gov/pubmed/32503625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00354-1
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