Randomized controlled trial of N-acetylcysteine therapy for RYR1-related myopathies

OBJECTIVE: To investigate the efficacy of N-acetylcysteine (NAC) for decreasing elevated oxidative stress and increasing physical endurance in individuals with ryanodine receptor 1-related myopathies (RYR1-RM). METHODS: In this 6-month natural history assessment (n = 37) followed by a randomized, do...

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Bibliografiske detaljer
Udgivet i:Neurology
Main Authors: Todd, Joshua J., Lawal, Tokunbor A., Witherspoon, Jessica W., Chrismer, Irene C., Razaqyar, Muslima S., Punjabi, Monal, Elliott, Jeffrey S., Tounkara, Fatoumata, Kuo, Anna, Shelton, Monique O., Allen, Carolyn, Cosgrove, Mary M., Linton, Melody, Michael, Darren, Jain, Minal S., Waite, Melissa, Drinkard, Bart, Wakim, Paul G., Dowling, James J., Bönnemann, Carsten G., Emile-Backer, Magalie, Meilleur, Katherine G.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2020
Fag:
Null Hypothesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274912/
https://ncbi.nlm.nih.gov/pubmed/31941795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000008872
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