Deleting Titin’s C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle

The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: van der Pijl, Robbert J., Hudson, Brian, Granzier-Nakajima, Tomotaroh, Li, Frank, Knottnerus, Anne M., Smith, John, Chung, Charles S., Gotthardt, Michael, Granzier, Henk L., Ottenheijm, Coen A. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274174/
https://ncbi.nlm.nih.gov/pubmed/32547410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00494
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