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Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O(2)-Rich Pigment Epithelium
When O(2) is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic environment by reversing the succinate dehydrogenase reaction t...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7273505/ https://ncbi.nlm.nih.gov/pubmed/32375026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107606 |
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