Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts

Irisin, a newly identified myokine, is critical to modulating body metabolism and biological homeostasis. However, whether irisin protects the skeletal muscles against metabolic stresses remains unknown. In this study, we determine the effect of irisin on high glucose and fatty acid-induced damages...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Yano, Naohiro, Zhang, Ling, Wei, Dennis, Dubielecka, Patrycja M., Wei, Lei, Zhuang, Shougang, Zhu, Ping, Qin, Gangjian, Liu, Paul Y., Chin, Y. Eugene, Zhao, Ting C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272726/
https://ncbi.nlm.nih.gov/pubmed/32182124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00219.2019
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