Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show that pericyte FAK regulates tumour growth and angiogenesis in...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272651/
https://ncbi.nlm.nih.gov/pubmed/32499572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16618-6
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