AP‐2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons

Cleavage of amyloid precursor protein (APP) by BACE‐1 (β‐site APP cleaving enzyme 1) is the rate‐limiting step in amyloid‐β (Aβ) production and a neuropathological hallmark of Alzheimer's disease (AD). Despite decades of research, mechanisms of amyloidogenic APP processing remain highly controv...

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Foilsithe in:EMBO Rep
Main Authors: Bera, Sujoy, Camblor‐Perujo, Santiago, Calleja Barca, Elena, Negrete‐Hurtado, Albert, Racho, Julia, De Bruyckere, Elodie, Wittich, Christoph, Ellrich, Nina, Martins, Soraia, Adjaye, James, Kononenko, Natalia L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271323/
https://ncbi.nlm.nih.gov/pubmed/32323475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947954
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