Combinatorial approach of in silico and in vitro evaluation of MLH1 variant associated with Lynch syndrome like metastatic colorectal cancer

Colorectal cancer (CRC) is the third most developing cancer worldwide and Lynch syndrome (LS) accounts for 3–4% of CRC. Genetic alteration in any of DNA mismatch repair (MMR) gene is the major cause of LS that disrupt the normal upstream and downstream MMR events. Germline mutation of MLH1 in hetero...

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Bibliographische Detailangaben
Veröffentlicht in:Biosci Rep
Hauptverfasser: Saleem, Komal, Zaib, Tahir, Ji, Wei, Zhang, Chunhui, Qin, Qian, Wang, Yusi, Xu, Lidan, Yu, Hanfei, Zhu, Siqi, Dong, Kexian, Si, Shuhan, Jia, Xueyuan, Wu, Jie, Fu, Songbin, Sun, Wenjing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2020
Schlagworte:
Bioinformatics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269917/
https://ncbi.nlm.nih.gov/pubmed/32432717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20200225
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