Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide

Temozolomide (TMZ) insensitivity and resistance are major causes of treatment failure and poor prognosis for GBM patients. Here, we identify LRRC4 as a novel autophagy inhibitor that restores the sensitivity of GBMs to TMZ. LRRC4 was associated with the DEPTOR/mTOR complex, and this interaction resu...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Feng, Jianbo, Zhang, Yan, Ren, Xing, Li, Di, Fu, Haijuan, Liu, Changhong, Zhou, Wen, Liu, Qing, Liu, Qiang, Wu, Minghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269909/
https://ncbi.nlm.nih.gov/pubmed/32372061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1312-6
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