Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide

Temozolomide (TMZ) insensitivity and resistance are major causes of treatment failure and poor prognosis for GBM patients. Here, we identify LRRC4 as a novel autophagy inhibitor that restores the sensitivity of GBMs to TMZ. LRRC4 was associated with the DEPTOR/mTOR complex, and this interaction resu...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Feng, Jianbo, Zhang, Yan, Ren, Xing, Li, Di, Fu, Haijuan, Liu, Changhong, Zhou, Wen, Liu, Qing, Liu, Qiang, Wu, Minghua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269909/
https://ncbi.nlm.nih.gov/pubmed/32372061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1312-6
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