Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8(+) T cells to memory T cells

Clinical response rates after adoptive cell therapy (ACT) are highly correlated with in vivo persistence of the infused T cells. However, antigen-specific T cells found in tumor sites are often well-differentiated effector cells with limited persistence. Central memory CD8(+) T cells, capable of sel...

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Pubblicato in:Cancer Immunol Res
Autori principali: Wang, Junmei, Hasan, Farah, Frey, Amanda C., Li, Haiyan S., Park, Jungsun, Pan, Ke, Haymaker, Cara, Bernatchez, Chantale, Lee, Dean A., Watowich, Stephanie S., Yee, Cassian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269845/
https://ncbi.nlm.nih.gov/pubmed/32213626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0619
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