Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease

Niemann-Pick type C (NPC)1 disease is a rare genetic condition in which the function of the lysosomal cholesterol transporter NPC1 protein is impaired. Consequently, sphingolipids and cholesterol accumulate in lysosomes of all tissues, triggering a cascade of pathological events that culminate in se...

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Bibliografische gegevens
Gepubliceerd in:J Lipid Res
Hoofdauteurs: Magro dos Reis, Inês, Houben, Tom, Oligschläger, Yvonne, Bücken, Leoni, Steinbusch, Hellen, Cassiman, David, Lütjohann, Dieter, Westerterp, Marit, Prickaerts, Jos, Plat, Jogchum, Shiri-Sverdlov, Ronit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2020
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269767/
https://ncbi.nlm.nih.gov/pubmed/32291331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000632
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