Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Niemann-Pick type C1 (NPC1) disease is caused by a deleterious mutation in the Npc1 gene, causing lysosomal accumulation of unesterified cholesterol and sphingolipids. Consequently, NPC1 disease patients suffer from severe neurovisceral symptoms which, in the absence of effective treatments, result...

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Udgivet i:Front Immunol
Main Authors: Houben, Tom, Magro dos Reis, Inês, Oligschlaeger, Yvonne, Steinbusch, Hellen, Gijbels, Marion J. J., Hendrikx, Tim, Binder, Christoph J., Cassiman, David, Westerterp, Marit, Prickaerts, Jos, Shiri-Sverdlov, Ronit
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330339/
https://ncbi.nlm.nih.gov/pubmed/30666257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03089
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