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The surprising complexity of K(ATP) channel biology and of genetic diseases

The ATP-sensitive K(+) channel (K(ATP)) is formed by the association of four inwardly rectifying K(+) channel (Kir6.x) pore subunits with four sulphonylurea receptor (SUR) regulatory subunits. Kir6.x or SUR mutations result in K(ATP) channelopathies, which reflect the physiological roles of these ch...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Zhao, Guiling, Kaplan, Aaron, Greiser, Maura, Lederer, W. Jonathan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269573/
https://ncbi.nlm.nih.gov/pubmed/32065592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135759
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