Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes

β-Lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1 were detected among laboratory-passaged β-lactam-resistant S. aureu...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Chatterjee, Aditi, Poon, Raymond, Chatterjee, Som S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269480/
https://ncbi.nlm.nih.gov/pubmed/32179529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02222-19
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