Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes. The broad-spectrum inhibitory activity of QPX7728 observed in biochemical exp...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Lomovskaya, Olga, Nelson, Kirk, Rubio-Aparicio, Debora, Tsivkovski, Ruslan, Sun, Dongxu, Dudley, Michael N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269478/
https://ncbi.nlm.nih.gov/pubmed/32229498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00552-20
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