Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes. The broad-spectrum inhibitory activity of QPX7728 observed in biochemical exp...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Lomovskaya, Olga, Nelson, Kirk, Rubio-Aparicio, Debora, Tsivkovski, Ruslan, Sun, Dongxu, Dudley, Michael N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269478/
https://ncbi.nlm.nih.gov/pubmed/32229498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00552-20
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