A Novel Deletion Mutation in pmrB Contributes to Concurrent Colistin Resistance in Carbapenem-Resistant Escherichia coli Sequence Type 405 of Clinical Origin

We report the first clinical Escherichia coli strain EC3000 with concomitant chromosomal colistin and carbapenem resistance. A novel in-frame deletion, Δ6-11 (RPISLR), in pmrB that contributes to colistin resistance was verified using recombinant DNA techniques. Although being less fit than the wild...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wang, Ching-Hsun, Siu, L. Kristopher, Chang, Feng-Yee, Tsai, Yu-Kuo, Lin, Yi-Tsung, Chiu, Sheng-Kang, Huang, Li-Yueh, Lin, Jung-Chung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269477/
https://ncbi.nlm.nih.gov/pubmed/32284375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00220-20
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