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Detecting Shared Genetic Architecture Among Multiple Phenotypes by Hierarchical Clustering of Gene-Level Association Statistics

Emerging large-scale biobanks pairing genotype data with phenotype data present new opportunities to prioritize shared genetic associations across multiple phenotypes for molecular validation. Past research, by our group and others, has shown gene-level tests of association produce biologically inte...

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Publicat a:Genetics
Autors principals: McGuirl, Melissa R., Smith, Samuel Pattillo, Sandstede, Björn, Ramachandran, Sohini
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268989/
https://ncbi.nlm.nih.gov/pubmed/32245788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303096
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