Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye

PURPOSE: To evaluate the prophylactic antiviral efficacy, corneal tolerance and toxicity of topically dosed BX795, a non-nucleoside small-molecule inhibitor of herpes simplex virus type-1 (HSV-1). METHODS: Prophylactic treatment with BX795 was performed both in-vitro on human corneal epithelial cell...

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Vydáno v:Ocul Surf
Hlavní autoři: Yadavalli, Tejabhiram, Suryawanshi, Rahul, Ali, Marwan, Iqbal, Aqsa, Koganti, Raghuram, Ames, Joshua, Aakalu, Vinay Kumar, Shukla, Deepak
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268978/
https://ncbi.nlm.nih.gov/pubmed/31770600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtos.2019.11.011
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