The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease

Synaptojanin 1 (SYNJ1) is a brain-enriched lipid phosphatase critically involved in autophagosomal/endosomal trafficking, synaptic vesicle recycling and metabolism of phosphoinositides. Previous studies suggest that SYNJ1 polymorphisms have significant impact on the age of onset of Alzheimer’s disea...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Ando, Kunie, Ndjim, Marième, Turbant, Sabrina, Fontaine, Gaëlle, Pregoni, Gustavo, Dauphinot, Luce, Yilmaz, Zehra, Suain, Valérie, Mansour, Salwa, Authelet, Michèle, De Dekker, Robert, Leroy, Karelle, Delatour, Benoît, Duyckaerts, Charles, Potier, Marie-Claude, Brion, Jean-Pierre
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268631/
https://ncbi.nlm.nih.gov/pubmed/32493451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00954-1
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