Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice

Alzheimer’s disease (AD) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites. Numerous experimental models have shown that tau pathology develops...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Houben, Sarah, de Fisenne, Marie-Ange, Ando, Kunie, Vanden Dries, Virginie, Poncelet, Luc, Yilmaz, Zehra, Mansour, Salwa, De Decker, Robert, Brion, Jean-Pierre, Leroy, Karelle
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381181/
https://ncbi.nlm.nih.gov/pubmed/32765217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00106
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