Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment

Juvenile myelomonocytic leukemia (JMML) is a rare aggressive myelodysplastic/myeloproliferative neoplasm of early childhood, initiated by RAS-activating mutations. Genomic analyses have recently described JMML mutational landscape; however, the nature of JMML-propagating cells (JMML-PCs) and the clo...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Caye, Aurélie, Rouault-Pierre, Kevin, Strullu, Marion, Lainey, Elodie, Abarrategi, Ander, Fenneteau, Odile, Arfeuille, Chloé, Osman, Jennifer, Cassinat, Bruno, Pereira, Sabrina, Anjos-Afonso, Fernando, Currie, Erin, Ariza-McNaughton, Linda, Barlogis, Vincent, Dalle, Jean-Hugues, Baruchel, André, Chomienne, Christine, Cavé, Hélène, Bonnet, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266742/
https://ncbi.nlm.nih.gov/pubmed/31776464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0662-y
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