Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells

Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene expression studies in acute promyelocytic leukemia (A...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Orfali, Nina, Shan‐Krauer, Deborah, O’Donovan, Tracey R., Mongan, Nigel P., Gudas, Lorraine J., Cahill, Mary R., Tschan, Mario P., McKenna, Sharon L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266268/
https://ncbi.nlm.nih.gov/pubmed/31820845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12614
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