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Functional rescue of cataract-causing αA-G98R-crystallin by targeted compensatory suppressor mutations in human αA-crystallin
The G98R mutation in αA-crystallin is associated with the onset of pre-senile cataract and is characterized biochemically by an increased oligomeric mass, altered chaperone function, and loss of structural stability over time. Thus far, it is not known whether the inherent instability caused by gain...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7266266/ https://ncbi.nlm.nih.gov/pubmed/31523965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00374 |
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