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Functional rescue of cataract-causing αA-G98R-crystallin by targeted compensatory suppressor mutations in human αA-crystallin
The G98R mutation in αA-crystallin is associated with the onset of pre-senile cataract and is characterized biochemically by an increased oligomeric mass, altered chaperone function, and loss of structural stability over time. Thus far, it is not known whether the inherent instability caused by gain...
Gardado en:
| Publicado en: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7266266/ https://ncbi.nlm.nih.gov/pubmed/31523965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00374 |
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